4-(Methylamino)-3-nitrobenzoyl chloride(CAS: 82357-48-0)

4-(Methylamino)-3-nitrobenzoyl chloride is a white crystalline solid with a molecular weight of approximately 287.07 g/mol. It exhibits low water solubility and good solubility in organic solvents such as dichloromethane and acetonitrile. Chemically, it is reactive, particularly towards nucleophiles, and can undergo substitution reactions and nitro reduction.

4-(Methylamino)-3-nitrobenzoyl chloride is synthesized by reacting 4-(methylamino)-3-nitrobenzoic acid with thionyl chloride in the presence of a catalytic amount of organic base, such as pyridine, at room temperature. The reaction yields the chloride in a high yield, with good regioselectivity.

4-(Methylamino)-3-nitrobenzoyl chloride is used in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It also finds applications in the polymer industry as a monomer for the production of functional polymers. Additionally, it is utilized in the electronics industry for the fabrication of sensors and semiconductors.

When handling 4-(Methylamino)-3-nitrobenzoyl chloride, it is essential to wear protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be properly decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.