4-Fluoro-3-methylbenzaldehyde(CAS: 135427-08-6)

4-Fluoro-3-methylbenzaldehyde is a colorless to light yellow liquid with a molecular weight of approximately 160.13 g/mol. It has a melting point of -38°C and a boiling point of 190°C. The compound is slightly soluble in water but miscible with common organic solvents. It is moderately reactive, particularly with nucleophiles and reducing agents.

4-Fluoro-3-methylbenzaldehyde is commonly synthesized via the method of acylation of 3-methyl-4-fluorophenol with acetyl chloride in the presence of a catalytic amount of aluminum chloride. This process provides good yield and selectivity, with careful control of reaction conditions ensuring the desired product is formed.

4-Fluoro-3-methylbenzaldehyde finds applications in the pharmaceutical industry, where it is used as a precursor for the synthesis of various drugs. It is also utilized in the production of certain polymers and as a component in the development of sensors and semiconductors.

When handling 4-Fluoro-3-methylbenzaldehyde, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat sources and oxidizing agents. In case of a spill, use an appropriate absorbent material and consult the Material Safety Data Sheet (MSDS) for further guidance.