(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide(CAS: 1357389-11-7)

(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide (CAS: 1357389-11-7) is a crystalline solid with a molecular weight of approximately 431.3 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO and DMF. Chemically, it is relatively stable but reactive towards nucleophiles. It exhibits good reactivity in the presence of strong bases or reducing agents.

(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide (CAS: 1357389-11-7) is synthesized through a multi-step process involving the coupling of an amino phenyl derivative with a cinnamyl pyrazole. Commonly, this is achieved using palladium catalysis under mild conditions. The synthesis typically yields a high purity product with good selectivity and moderate to high yield depending on the specific reaction conditions.

(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide (CAS: 1357389-11-7) is primarily used in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It is also explored in polymer chemistry for its functional groups, which can aid in the development of new materials. Its use in sensors and semiconductor applications is also being investigated due to its chemical reactivity and functional diversity.

When handling (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide (CAS: 1357389-11-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. In case of eye or skin contact, flush with copious amounts of water and seek medical attention. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.