5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole(CAS: 862723-42-0)

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is a crystalline solid with a molecular weight of approximately 342.21 g/mol. It has a low solubility in water but good solubility in organic solvents such as dichloromethane and acetonitrile. The compound is known for its stability and low reactivity under normal conditions, making it suitable for various chemical reactions.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is typically synthesized via the reaction of indazole with 1,3,2-dioxaborine-2-yl triflate in the presence of a base like potassium tert-butoxide. The reaction is carried out under inert conditions to ensure high selectivity and yield. The process involves the formation of a boron-containing intermediate which then couples with indazole to form the final product.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and also finds application in the production of advanced polymers due to its unique structural properties.

When handling 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, it should be contained and cleaned up using appropriate absorbents, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.