1,2,3-Trifluoro-5-iodobenzene(CAS: 170112-66-0)

1,2,3-Trifluoro-5-iodobenzene is a solid, crystalline compound with a high molecular weight due to the presence of iodine and fluorine. It has a low solubility in water but good solubility in organic solvents such as chloroform and dichloromethane. The compound is not highly reactive under normal conditions but can undergo substitution reactions. Its molecular weight is approximately 311.01 Da. It is often used in organic synthesis and as an intermediate in the production of other fluorinated compounds.

1,2,3-Trifluoro-5-iodobenzene can be synthesized via a multi-step process involving the introduction of fluorine and iodine into a benzene ring. A common approach involves the use of trifluoromethylating reagents like trifluoromethyl iodide and a halogenating agent like N-bromosuccinimide (NBS) to introduce the trifluoro and iodine functionalities, respectively. The reaction conditions and catalysts are crucial for achieving high selectivity and yield.

1,2,3-Trifluoro-5-iodobenzene is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and fluorinated polymers. Additionally, it finds applications in the development of sensors and semiconductors due to its unique chemical properties.

When handling 1,2,3-Trifluoro-5-iodobenzene, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin and eye contact. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Proper spill handling procedures should be followed, and the substance should be stored in a cool, dry place away from heat sources. Always consult the Safety Data Sheet (SDS) for comprehensive safety information.