1,3-Bis(chloromethyl) Benzene(CAS: 626-16-4)

1,3-Bis(chloromethyl) Benzene (CAS: 626-16-4) is a colorless crystalline solid at room temperature. It has a molecular weight of approximately 193.06 g/mol and a melting point of 55.5°C. This compound is poorly soluble in water but soluble in organic solvents like benzene and toluene. It is a reactive compound, showing affinity for nucleophiles and can undergo substitution reactions easily.

1,3-Bis(chloromethyl) Benzene is typically synthesized by the reaction of chloromethylbenzene with bromine in the presence of sodium hydroxide, followed by hydrolysis of the bromide. The overall process is selective and yields high purity products. Commonly, this is carried out in an inert solvent such as tetrahydrofuran (THF) to ensure safety and high yield.

1,3-Bis(chloromethyl) Benzene (CAS: 626-16-4) is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of active pharmaceutical ingredients (APIs). It is also utilized in the production of polymers and as a raw material for the development of sensors and semiconductors due to its unique reactivity and chemical properties.

When handling 1,3-Bis(chloromethyl) Benzene (CAS: 626-16-4), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from flammable materials. Fume hoods should be used during synthesis and handling to minimize exposure. In the event of a spill, immediate action should be taken according to the safety data sheet (SDS) to ensure safety and proper disposal.