Compound Q&A

How is 1,3-Bis(chloromethyl) Benzene (CAS: 626-16-4) typically synthesized?

Answer

1,3-Bis(chloromethyl) Benzene
1,3-Bis(chloromethyl) Benzene is typically synthesized by the reaction of chloromethylbenzene with bromine in the presence of sodium hydroxide, followed by hydrolysis of the bromide. The overall process is selective and yields high purity products. Commonly, this is carried out in an inert solvent such as tetrahydrofuran (THF) to ensure safety and high yield.

About

CAS No 626-16-4
English Name 1,3-Bis(chloromethyl) Benzene
Molecular Formula C8H8Cl2
Molecular Weight 175.06 g/mol
SMILES C1=CC(=CC(=C1)CCl)CCl
InChIKey GRJWOKACBGZOKT-UHFFFAOYSA-N
Last Updated: 2025-09-07 10:18

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