3-Pyridazinecarboxylic acid(CAS: 2164-61-6)

3-Pyridazinecarboxylic acid is a crystalline solid with a molecular weight of approximately 143.12 g/mol. It has a melting point of 212-214°C and is slightly soluble in water. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is typically stored in a closed container to protect it from moisture and air exposure.

3-Pyridazinecarboxylic acid can be synthesized via the condensation of 3-pyridazinecarboxaldehyde with hydroxylamine. The reaction is typically conducted under mild conditions using a catalytic amount of a Lewis acid like aluminum trichloride to improve yield and selectivity. The product can be purified by recrystallization from an appropriate solvent.

3-Pyridazinecarboxylic acid finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the polymer industry for the development of functional polymers and in the sensor industry for its ability to respond to specific chemical analytes. Additionally, it is used in the semiconductor industry due to its electronic properties.

When handling 3-Pyridazinecarboxylic acid, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. It should be stored in a cool, dry place away from heat and incompatible materials. If a spill occurs, it should be carefully cleaned up with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.