Candesartan Cilexetil Impurity 9(CAS: 136285-67-1)

Candesartan Cilexetil Impurity 9 (CAS: 136285-67-1) is a white to off-white crystalline powder. Its molecular weight is approximately 484.57 g/mol. This impurity is slightly soluble in water and ethanol. It is relatively stable under normal conditions but may react with strong acids or bases. Detailed physicochemical properties include melting point (about 110-115°C) and density (1.58 g/cm³).

Candesartan Cilexetil Impurity 9 (CAS: 136285-67-1) is synthesized via a multistep process involving acylation, cyclization, and esterification reactions. Common catalysts used include sulfonyl chlorides and carboxylic acids. The synthesis typically achieves a yield of around 75%, with high selectivity towards the desired impurity. Detailed synthetic routes and purification methods can be found in chemical literature.

Candesartan Cilexetil Impurity 9 (CAS: 136285-67-1) is primarily used in the pharmaceutical industry, particularly in the production of candesartan cilexetil, a vasopressor agent used to treat hypertension. It also finds applications in research and development for drug screening and quality control. Its presence is monitored to ensure the purity of the final drug product.

When handling Candesartan Cilexetil Impurity 9 (CAS: 136285-67-1), it is essential to use appropriate personal protective equipment (PPE) such as gloves, lab coats, and safety goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly washed down. Refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.