1,2,5-Oxadiazol-3-ylmethanol(CAS: 79552-35-5)

1,2,5-Oxadiazol-3-ylmethanol is a crystalline solid with a molecular weight of approximately 127.14 g/mol. Its solubility in water is low, but it is soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly in nucleophilic substitution reactions.

1,2,5-Oxadiazol-3-ylmethanol is commonly synthesized via the reaction of 3-formyl-1,2,5-oxadiazole with methanol. This synthesis typically employs a catalytic amount of a suitable acid like sulfuric acid and proceeds under mild conditions. The yield is around 85%, and the reaction is selective for the methanol addition to the 3-formyl group.

1,2,5-Oxadiazol-3-ylmethanol is used in various industries, including pharmaceuticals for intermediate applications, polymer science for functionalization of polymers, and sensing technology due to its reactivity and stability. It also plays a role in semiconductor manufacturing for specific chemical processes.

When handling 1,2,5-Oxadiazol-3-ylmethanol, it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. Ensure the use of a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate chemicals, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.