2-Chloro-5-methoxyaniline(CAS: 2401-24-3)

2-Chloro-5-methoxyaniline (CAS: 2401-24-3) is a white to off-white crystalline solid with a molecular weight of approximately 191.64 g/mol. It has a melting point of 103-105°C and is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is moderately reactive, particularly towards nucleophiles and reducing agents.

2-Chloro-5-methoxyaniline (CAS: 2401-24-3) can be synthesized through the reaction of 5-methoxyaniline with chlorine gas in the presence of a phase transfer catalyst, such as tetrabutylammonium bromide. The yield is typically around 80-85%, with the product isolated by recrystallization from suitable solvents.

2-Chloro-5-methoxyaniline (CAS: 2401-24-3) finds applications in various industries. It is used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of antiviral drugs. It also serves as a precursor for the preparation of dyes, pigments, and resins. Additionally, it has limited use in the development of sensors and semiconductors.

Handling 2-Chloro-5-methoxyaniline (CAS: 2401-24-3) requires the use of personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or within a fume hood to minimize exposure to vapors. Spills should be cleaned up carefully using appropriate absorbent materials. For safety information, always refer to the Safety Data Sheet (SDS) for detailed guidelines.