2-Iodo-5-methylbenzoic acid(CAS: 52548-14-8)

2-Iodo-5-methylbenzoic acid (CAS: 52548-14-8) is a solid crystalline compound with a molecular weight of approximately 251.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetonitrile. Chemically, it is reactive towards bases and can undergo substitution reactions. It is typically used in organic synthesis and as an intermediate in the development of pharmaceuticals and other materials.

2-Iodo-5-methylbenzoic acid (CAS: 52548-14-8) is typically synthesized through the iodination of 5-methylbenzoic acid using iodine and a Lewis acid catalyst, such as aluminum chloride. The reaction is carried out in an organic solvent like dichloromethane. The yield is generally around 75-85%, and the selectivity towards the iodo-substitution is high.

2-Iodo-5-methylbenzoic acid (CAS: 52548-14-8) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the development of polymers and sensors due to its functional groups. Its reactivity makes it useful in semiconductor manufacturing processes.

When handling 2-Iodo-5-methylbenzoic acid (CAS: 52548-14-8), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. The compound should be stored in a cool, dry place away from sources of heat and moisture. Spills should be immediately contained and cleaned up using absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.