5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-one(CAS: 113502-52-6)

5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-one (CAS: 113502-52-6) is a white or off-white crystalline solid with a molecular weight of approximately 246.24 g/mol. It has a pKa of around 4.3, indicating it is slightly acidic. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is reactive, especially towards nucleophiles and can undergo reactions such as condensation and substitution.

5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-one (CAS: 113502-52-6) is typically synthesized via a multistep process starting with benzoic acid and pyrrolidine. The synthesis involves the formation of an amide, followed by a ring closure reaction. Common catalysts include stoichiometric bases like sodium hydride and acids like trifluoroacetic acid. The overall yield can range from 70% to 85%.

5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-one (CAS: 113502-52-6) finds applications in pharmaceuticals, particularly as a precursor for drug synthesis. It is also used in the production of sensors and as a chemical intermediate in the synthesis of polymers with unique properties. Additionally, it plays a role in the development of materials for electronic devices due to its electronic characteristics.

When handling 5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-one (CAS: 113502-52-6), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully using appropriate absorbents, and the area should be thoroughly cleaned. Always consult the Safety Data Sheet (SDS) for detailed handling and spill procedures.