8-Chloroquinoline-5-carboxylic acid(CAS: 121490-68-4)

8-Chloroquinoline-5-carboxylic acid is a white or off-white crystalline solid with a molecular weight of approximately 219.02 g/mol. It has a pKa of about 4.0 and is slightly soluble in water. The compound exhibits mild acidity and can participate in esterification and other reactions typical of carboxylic acids. It is moderately reactive towards bases and nucleophiles.

8-Chloroquinoline-5-carboxylic acid is commonly synthesized via the condensation of 8-chloroquinoline with an acylating agent such as a carboxylic anhydride or acid chloride. The reaction is typically performed under mild conditions, and the yield can be improved by using appropriate catalysts and optimizing reaction parameters.

8-Chloroquinoline-5-carboxylic acid finds applications in the pharmaceutical industry as a precursor for the synthesis of certain drugs, particularly those involving quinoline-based scaffolds. It is also used in polymer science for the modification of polymer properties and in the development of sensors and semiconductors.

When handling 8-Chloroquinoline-5-carboxylic acid, wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight and flammable materials. Use a fume hood during handling and disposal. Ensure proper ventilation and follow the Material Safety Data Sheet (MSDS) for all disposal procedures.