Fluticasone(CAS: 90566-53-3)

Fluticasone (CAS: 90566-53-3) is a white to off-white crystalline powder. Its molecular formula is C21H25FO5, with a molecular weight of 361.43 g/mol. It has moderate solubility in water (0.029 mg/mL) and is poorly soluble in most organic solvents. Fluticasone is a potent corticosteroid with low reactivity under normal conditions, making it stable to heat and light.

Fluticasone is synthesized via a multi-step process, often involving the reduction of a tetrahydrofuran derivative to form the key intermediate. This intermediate is then reacted with 2,2,2-trifluoro-1,1-dichloroethane to yield the desired compound. The synthesis typically requires the use of hydrogen, sodium borohydride, and trifluoroacetic anhydride. The overall yield is generally between 60-70%, with high selectivity towards the target product.

Fluticasone (CAS: 90566-53-3) is primarily used in the pharmaceutical industry, specifically for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It is also of interest in the cosmetics industry due to its anti-inflammatory properties. In addition, it has applications in the research field for studying corticosteroid receptors and mechanisms.

When handling Fluticasone (CAS: 90566-53-3), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be performed in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be handled carefully, using appropriate absorbent materials and ensuring they are disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.