2,4-Dichlorobenzoyl chloride(CAS: 89-75-8)

2,4-Dichlorobenzoyl chloride (CAS: 89-75-8) is a white crystalline solid with a molecular weight of 216.02 g/mol. It has a low solubility in water (0.02 g/100 mL at 20°C) but is more soluble in organic solvents like methanol and ethanol. It is highly reactive, particularly with nucleophiles, and dehydrates to form 2,4-dichlorobenzoyl hydrochloride under basic conditions.

2,4-Dichlorobenzoyl chloride is typically synthesized by the reaction of 2,4-dichlorobenzoic acid with thionyl chloride. The reaction is carried out under anhydrous conditions to improve yield and selectivity. Additional methods include the chlorination of benzoic acid or 2,4-dichlorobenzoic acid with phosphorus oxychloride or phosphorus chlorochloridate.

2,4-Dichlorobenzoyl chloride is used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also utilized in the polymer industry as a monomer for the production of various polymer materials, in the sensor industry for developing gas sensors, and in the semiconductor industry for certain etching processes.

When handling 2,4-Dichlorobenzoyl chloride (CAS: 89-75-8), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. It should be handled under a fume hood due to its strong volatility and reactivity. Proper spill handling procedures should be followed, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.