3-Amino-5-fluoro-6-methoxypyridine(CAS: 886372-63-0)

3-Amino-5-fluoro-6-methoxypyridine is a crystalline solid with a molecular formula C8H7FN2O and a molecular weight of approximately 173.15 g/mol. It has a high solubility in water and methanol, poor solubility in hexane. The compound shows moderate reactivity, particularly towards nucleophiles. It is commonly used in organic synthesis and pharmaceuticals.

3-Amino-5-fluoro-6-methoxypyridine is typically synthesized through the reaction of 5-fluoro-6-methoxypyridine with an amine in the presence of a base such as sodium hydroxide. This method provides good yield and selectivity. The reaction is carried out in an organic solvent like dimethylformamide (DMF) at elevated temperatures.

3-Amino-5-fluoro-6-methoxypyridine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the chemical industry for the development of sensors and semiconductors due to its unique electronic properties.

When handling 3-Amino-5-fluoro-6-methoxypyridine, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be handled with a fume hood to avoid inhalation. Always refer to the safety data sheet (SDS) for detailed handling and safety instructions.