Ethyl 4-amino-6-chloro-5-iodonicotinate(CAS: 1935952-84-3)

Ethyl 4-amino-6-chloro-5-iodonicotinate is a crystalline compound with a molecular weight of approximately 422.85 g/mol. It is poorly soluble in water but soluble in common organic solvents like methanol and ethanol. This compound is known for its reactivity towards nucleophilic substitution reactions due to the presence of the amino and halide groups.

Ethyl 4-amino-6-chloro-5-iodonicotinate is synthesized through a multi-step process involving condensation reactions and halogenation. It typically requires the use of catalysts such as N,N'-carbonyldiimidazole (CDI) for the amidation step and iodine for the halogenation step. The overall reaction involves the introduction of an amino group and subsequent halogenation, leading to the desired compound.

Ethyl 4-amino-6-chloro-5-iodonicotinate is primarily used in the pharmaceutical industry for the synthesis of certain drugs due to its unique functional groups. It may also have applications in research and development, particularly in studies related to organic synthesis and medicinal chemistry.

When handling Ethyl 4-amino-6-chloro-5-iodonicotinate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up carefully following standard laboratory procedures, and the material safety data sheet (MSDS) should be consulted for specific guidance.