Methyl 5-bromo-2-chloro-3-methoxybenzoate(CAS: 697762-67-7)

Methyl 5-bromo-2-chloro-3-methoxybenzoate is a crystalline solid with a molecular weight of approximately 321.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It has a melting point around 80-82°C.

Methyl 5-bromo-2-chloro-3-methoxybenzoate is commonly synthesized through a series of reactions starting from 3-methoxybenzoic acid. The process involves bromination, followed by chlorination, and esterification using methanol. The reaction conditions typically include the use of aluminum bromide and aluminum chloride as catalysts, with high yields and good selectivity.

Methyl 5-bromo-2-chloro-3-methoxybenzoate is primarily used in the pharmaceutical industry for the synthesis of intermediates. It also has applications in the polymer industry, where it can serve as a precursor for the production of specialized polymers. Additionally, it is used in the sensor and semiconductor industries for the fabrication of certain electronic components.

When handling Methyl 5-bromo-2-chloro-3-methoxybenzoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and laboratory coat. Work must be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be ventilated. The safety data sheet (SDS) should be consulted for detailed emergency response procedures.