Acalabrutinib(CAS: 1420477-60-6)

Acalabrutinib (CAS: 1420477-60-6) is a crystalline compound with a molecular weight of approximately 519.57 g/mol. It is moderately soluble in aqueous solutions and has poor solubility in common organic solvents. Acalabrutinib is chemically stable under normal laboratory conditions but can degrade upon exposure to light and heat. It is highly selective for Bruton's tyrosine kinase (BTK), which makes it an effective inhibitor for treating certain types of blood cancers.

Acalabrutinib (CAS: 1420477-60-6) is synthesized through a multi-step process involving the modification of a defined starting material. The synthesis typically involves a series of reactions including alkylation, amination, and acylation, with the use of specific catalysts and reagents. The final step involves purification and crystallization to obtain the desired product. The overall yield is around 50-60%, with high selectivity towards the target compound.

Acalabrutinib (CAS: 1420477-60-6) is primarily used in the pharmaceutical industry for the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It has also shown promise in other hematological disorders and is being explored for its potential applications in oncology research. While not widely used in other industries, its unique properties make it a valuable research compound in areas such as drug discovery and development.

When handling Acalabrutinib (CAS: 1420477-60-6), it is important to wear personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, the area should be ventilated, and chemical spill kits should be readily available. It is advisable to consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions. Acalabrutinib should never be ingested or inhaled, and proper disposal of unused or expired material should follow local regulations for hazardous chemicals.