Azacitidine(CAS: 320-67-2)

Azacitidine is a synthetic nucleoside analog with the chemical formula C9H12N4O4. It is known for its ability to inhibit DNA methylation and is used primarily in medical applications. As a cytosine analog, it has structural similarities to DNA bases and is often employed in cancer treatment, particularly for myelodysplastic syndromes. Its molecular structure and chemical properties make it a valuable compound in pharmaceutical research.

Azacitidine is mainly used in the treatment of certain blood cancers, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It works by altering gene expression through DNA hypomethylation. Additionally, it is utilized in research for studying epigenetic mechanisms and has potential applications in other therapeutic areas. Its role as a DNA methyltransferase inhibitor makes it a key compound in oncology and molecular biology.

Azacitidine is generally considered safe when used as directed in medical settings. However, it can cause side effects such as nausea, vomiting, and myelosuppression. Proper handling and protective measures, like using gloves and ensuring good ventilation, are essential during its preparation and administration. Safety standards for Azacitidine are established by regulatory bodies to ensure its appropriate use in clinical and research contexts.

Azacitidine should be stored in a cool, dry place away from light. It is typically kept in airtight containers at a temperature range of 2-8°C. Maintaining low humidity levels is crucial to prevent degradation. Proper storage ensures the stability and potency of the compound, which is important for both pharmaceutical and research applications.