3-(2-Methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxylic acid(CAS: 93041-44-2)

3-(2-Methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxylic acid is a white to off-white crystalline solid with a molecular weight of approximately 232.25 g/mol. It has a solubility of about 4.5 mg/mL in water at 25°C. This compound is relatively stable in dry conditions but can hydrolyze in the presence of moisture. It is not highly reactive but can participate in esterification reactions under appropriate conditions.

3-(2-Methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxylic acid can be synthesized via a multistep approach, starting with 2-methoxybenzaldehyde and methyl acetoacetate. The key steps involve condensation, protection, deprotection, and final acylation. This synthesis typically uses mild reagents and conditions to ensure high yield and selectivity. Commonly, catalysts like p-toluidine or p-toluenesulfonic acid are used.

3-(2-Methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxylic acid finds applications in the pharmaceutical industry as an intermediate for the synthesis of certain drugs, particularly in the development of antifungal and antiviral compounds. It is also utilized in the chemical industry for the preparation of polymers and in the manufacturing of sensors and semiconductors.

When handling 3-(2-Methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxylic acid, ensure the use of appropriate personal protective equipment (PPE) including gloves and lab coat. Store it in a cool, dry environment away from direct sunlight and moisture. Use a fume hood during preparation and handling to minimize inhalation risk. Always refer to the Safety Data Sheet (SDS) for detailed safety information and guidelines. Do not ingest or come into contact with the eyes or skin.