Isopropyl (2Z)-3-amino-2-butenoate(CAS: 14205-46-0)

Isopropyl (2Z)-3-amino-2-butenoate (CAS: 14205-46-0) is a crystalline solid with a molecular weight of approximately 125.15 g/mol. It has a pKa of around 8.5, making it slightly basic. The compound is poorly soluble in water but soluble in organic solvents like ethanol and acetone. It is known for its reactivity, particularly in nucleophilic addition reactions and amidation reactions.

Isopropyl (2Z)-3-amino-2-butenoate (CAS: 14205-46-0) can be synthesized via a multi-step process, starting with the preparation of (2Z)-3-bromo-2-butenoic acid isopropyl ester. This ester is then reacted with an excess of (S)-4-aminobutanol in the presence of a suitable base like sodium hydroxide to form the amine. The reaction is typically performed in an anhydrous, inert atmosphere to prevent side reactions.

Isopropyl (2Z)-3-amino-2-butenoate (CAS: 14205-46-0) finds application in various industries. It is primarily used in the pharmaceutical sector for the synthesis of active pharmaceutical ingredients (APIs) due to its ability to form stable amide bonds. It is also utilized in the polymer industry for modifying polymer properties and in the semiconductor industry for use in photolithography materials.

When handling Isopropyl (2Z)-3-amino-2-butenoate (CAS: 14205-46-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and laboratory coat. Work should be carried out in a fume hood to minimize exposure. Spills should be neutralized with appropriate reagents and cleaned up carefully. Always consult the safety data sheet (SDS) for detailed safety information and emergency procedures.