(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol(CAS: 225920-05-8)

(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a colorless or white crystalline solid with a molecular weight of approximately 262.11 g/mol. It has a low solubility in water (less than 1 g/L) but is more soluble in organic solvents like dichloromethane and acetone. The compound is known for its high reactivity, particularly with transition metals and strong acids.

(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is typically synthesized via stereoselective reduction of (1R,3S)-1-(3,5-bis(trifluoromethyl)phenyl)-2,2-difluoroethylene. Commonly, this involves the use of lithium aluminum hydride (LAH) as a reducing agent under anhydrous conditions in ether. The reaction is carried out at low temperatures to achieve high selectivity and yield.

(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is utilized in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also employed in the polymer industry for developing novel materials with specific properties. Additionally, it has applications in sensor technology and semiconductor manufacturing due to its unique chemical characteristics.

When handling (1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or under a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly decontaminated. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.