Compound Q&A
How is (1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol (CAS: 225920-05-8) typically synthesized?
Answer
![(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol](https://static.chemtradehub.com/structs/225/225920-05-8-fdd3.webp "(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol")
(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is typically synthesized via stereoselective reduction of (1R,3S)-1-(3,5-bis(trifluoromethyl)phenyl)-2,2-difluoroethylene. Commonly, this involves the use of lithium aluminum hydride (LAH) as a reducing agent under anhydrous conditions in ether. The reaction is carried out at low temperatures to achieve high selectivity and yield.
About
CAS No
225920-05-8
English Name
(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Molecular Formula
C10H8F6O
Molecular Weight
258.16 g/mol
SMILES
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O
InChIKey
MMSCIQKQJVBPIR-YFKPBYRVSA-N
Last Updated: 2025-09-08 00:42
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