1-(3-Methylphenyl)-1-propanone(CAS: 51772-30-6)

1-(3-Methylphenyl)-1-propanone is a colorless liquid with a molecular weight of approximately 142.21 g/mol. It has a density of about 0.91 g/cm³ and a boiling point of around 134°C. The compound is slightly soluble in water but miscible with common organic solvents. It is reactive towards bases and some oxidizing agents.

1-(3-Methylphenyl)-1-propanone can be synthesized through a Wittig reaction of 3-methylbenzyl alcohol with triphenylphosphine and acrylonitrile. The reaction is performed in the presence of a Lewis acid catalyst, such as aluminum trichloride, to improve yield and selectivity. The process typically yields 85-90% of the desired product.

1-(3-Methylphenyl)-1-propanone is primarily used in the pharmaceutical industry for the synthesis of intermediates and precursors. It is also utilized in polymer production, as a starting material for sensors, and in the electronics sector for the fabrication of semiconductors.

When handling 1-(3-Methylphenyl)-1-propanone, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, well-ventilated area away from heat sources and oxidizing agents. In the event of a spill, it should be contained and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.