Cinobufotalin(CAS: 1108-68-5)

Cinobufotalin is a cyclic steroid alkaloid. It appears as a white or off-white crystalline powder. The molecular weight is approximately 468.44 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and methanol. Cinobufotalin is less reactive chemically but can undergo hydrolysis under basic conditions. It has a melting point of about 220-222°C.

Cinobufotalin is typically synthesized from the bufadienolide bufotalin using a series of reactions including acetylation, alkylation, and cyclization. The process involves the use of appropriate solvents and catalysts, and the overall yield is moderate. The exact conditions and reagents can vary depending on the specific synthesis route chosen.

Cinobufotalin is primarily used in the pharmaceutical industry for its cardiotonic and antiarrhythmic properties. It is also used in some research applications in the biological and medical sectors due to its pharmacological effects. There are limited applications in other industries such as polymer research, but its use is more specialized.

When handling Cinobufotalin, it is important to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. It should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate methods and materials. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.