1-(2-Bromo-4-hydroxyphenyl)ethanone(CAS: 61791-99-9)

1-(2-Bromo-4-hydroxyphenyl)ethanone is a white crystalline solid with a molecular weight of 254.03 g/mol. It has a high solubility in organic solvents such as methanol and acetone but is less soluble in water. It is relatively unreactive under normal conditions but can undergo bromination and oxidation reactions. The compound is stable at room temperature but should be stored in a cool, dark, and dry place to prevent photo-degradation.

1-(2-Bromo-4-hydroxyphenyl)ethanone is typically synthesized via the bromination of 4-hydroxyacetophenone using N-bromosuccinimide (NBS) as a brominating agent in the presence of a radical initiator like benzoyl peroxide. The reaction is usually performed in a chloroform or dichloromethane solvent at room temperature, yielding a high purity product with good selectivity and yield.

1-(2-Bromo-4-hydroxyphenyl)ethanone is used in the pharmaceutical industry for the synthesis of certain drug compounds. It is also utilized in the polymer industry for modifying polymer properties and enhancing their performance. Additionally, it is employed in the production of sensors and semiconductors for its unique chemical and physical properties.

When handling 1-(2-Bromo-4-hydroxyphenyl)ethanone, use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store the compound in a cool, dark, and dry place to prevent degradation. Work in a fume hood to minimize exposure to vapors. In case of a spill, immediately evacuate the area and clean up according to standard procedures. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.