[3-(Methylcarbamoyl)phenyl]boronic acid(CAS: 832695-88-2)

[3-(Methylcarbamoyl)phenyl]boronic acid is a white or off-white crystalline solid with a molecular weight of approximately 268.27 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetonitrile. Chemically, it shows basic properties due to the presence of the phenolic hydroxyl group and the boronic acid moiety. It is known for its stability in the solid state but can react with strong acids and bases. Its reactivity is mainly attributed to the boronic acid functionality, which makes it suitable for reactions like Suzuki coupling.

[3-(Methylcarbamoyl)phenyl]boronic acid can be synthesized via the reaction of 3-methylcarbamoylphenol with boronic acid. The synthesis typically involves the protection of the phenolic hydroxyl group to prevent unwanted side reactions, followed by the introduction of the boronic acid moiety. Commonly, this is achieved using an organoborane reagent in the presence of a base. The yield can be quite high, and the selectivity is generally good, making it a practical method for producing this compound.

[3-(Methylcarbamoyl)phenyl]boronic acid is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various medicinal compounds due to its reactivity at the boronic acid site. In the polymer industry, it can be used as a functional monomer to improve the properties of polymers. Additionally, it has applications in sensor technology and semiconductor manufacturing, where its chemical properties make it useful for specific analytical and electronic applications.

When handling [3-(Methylcarbamoyl)phenyl]boronic acid (CAS: 832695-88-2), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be managed in a well-ventilated area, ideally with a fume hood to prevent inhalation of dust. Spills should be cleaned up with care, using appropriate absorbents, and the area should be thoroughly cleaned with water and a mild detergent. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions to ensure safety in the laboratory setting.