(2,6-Dimethyl-3-pyridinyl)boronic acid(CAS: 693774-55-9)

(2,6-Dimethyl-3-pyridinyl)boronic acid is a white crystalline solid with a molecular weight of approximately 214.25 g/mol. It has a moderate solubility in organic solvents like ethanol and poor solubility in water. The compound shows limited reactivity, primarily in esterification reactions due to the boronic acid functionality. It is stable under normal conditions but should be stored in a cool, dry place to prevent moisture absorption.

(2,6-Dimethyl-3-pyridinyl)boronic acid can be synthesized through the reaction of 2,6-dimethylpyridine with boron tribromide in the presence of a Lewis acid catalyst like aluminum trichloride. This method provides a high yield and good selectivity. The reaction proceeds via an electrophilic aromatic substitution followed by a boration step.

(2,6-Dimethyl-3-pyridinyl)boronic acid finds applications in pharmaceuticals for the synthesis of drugs, polymers for advanced material science, and sensors in analytical chemistry. Its use in semiconductors is limited due to its low reactivity, but it is valuable in specific synthetic procedures where boronic acids are required.

When handling (2,6-Dimethyl-3-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Store the compound in a cool, dry place to prevent moisture absorption. Use a fume hood during handling to minimize exposure to vapors. In case of a spill, promptly clean up using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for proper disposal.