5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide(CAS: 1082745-50-3)

5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide is a solid with a crystalline form. Its molecular weight is approximately 300.34 g/mol. It has a high solubility in polar solvents like DMSO and moderate solubility in water. The compound is moderately reactive and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide is typically synthesized via a multistep process involving the condensation of an appropriate 1H-pyrazole-4-carboxamide with tetrahydro-2H-pyran-4-amine. The reaction is performed under basic conditions using a catalyst such as sodium hydride. The yield is generally around 70-80%, and the method is selective for the desired product.

5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide finds applications in the pharmaceutical industry due to its potential as a drug candidate. It is also used in the development of sensors and as an intermediate in the synthesis of other compounds. Its properties make it suitable for research in semiconductors and polymers.

When handling 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide, it is important to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or within a fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.