4,4,5,5-Tetramethyl-2-(2-methyl-5-nitrophenyl)-1,3,2-dioxaborolane(CAS: 957062-84-9)

4,4,5,5-Tetramethyl-2-(2-methyl-5-nitrophenyl)-1,3,2-dioxaborolane is a solid with a crystalline form. It has a molecular weight of approximately 330.06 g/mol. This compound is slightly soluble in common organic solvents like dichloromethane and toluene. It is moderately reactive, particularly towards electron-rich substrates in Suzuki coupling reactions.

4,4,5,5-Tetramethyl-2-(2-methyl-5-nitrophenyl)-1,3,2-dioxaborolane is synthesized through a multistep process that begins with the nitration of a phenylboronic acid derivative, followed by a coupling reaction under microwave-assisted conditions. This method ensures high yield and selectivity, often employing palladium catalysts and base additives.

4,4,5,5-Tetramethyl-2-(2-methyl-5-nitrophenyl)-1,3,2-dioxaborolane is primarily used in the pharmaceutical and polymer industries. It plays a crucial role in the synthesis of drug intermediates and as a monomer in the development of new polymers with unique properties. Additionally, it finds applications in the electronics industry for the production of semiconductors and sensors.

When handling 4,4,5,5-Tetramethyl-2-(2-methyl-5-nitrophenyl)-1,3,2-dioxaborolane, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.