Ethyl 2-bromo-1,3-thiazole-5-carboxylate(CAS: 41731-83-3)

Ethyl 2-bromo-1,3-thiazole-5-carboxylate (CAS: 41731-83-3) is a crystalline compound with a molecular weight of approximately 235.04 g/mol. It is slightly soluble in water but readily dissolves in organic solvents like ethanol and acetone. The compound exhibits limited reactivity, primarily undergoing nucleophilic substitution reactions due to the bromine atom and carboxylic acid ester functionality.

Ethyl 2-bromo-1,3-thiazole-5-carboxylate (CAS: 41731-83-3) is typically synthesized through the reaction of 1,3-thiazole-5-carboxylic acid with bromoethylamine. This process involves the substitution of the amine group with a bromoethyl group, followed by esterification with ethanol. The reaction is catalyzed by a suitable base like sodium hydride and proceeds with good selectivity and a yield of up to 85%.

Ethyl 2-bromo-1,3-thiazole-5-carboxylate (CAS: 41731-83-3) is used in the pharmaceutical industry for the preparation of various medicinal compounds. It is also utilized in the polymer industry for the modification of polymer properties and in sensor technology for detecting specific chemical species. Additionally, it finds applications in semiconductor manufacturing processes where its electronic properties are exploited.

When handling Ethyl 2-bromo-1,3-thiazole-5-carboxylate (CAS: 41731-83-3), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be stored in a well-ventilated area, away from direct sunlight and heat sources. In case of spillage, it should be immediately cleaned up using appropriate absorbent materials and the spill site should be decontaminated. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.