How is Ethyl 2-bromo-1,3-thiazole-5-carboxylate (CAS: 41731-83-3) typically synthesized?

Ethyl 2-bromo-1,3-thiazole-5-carboxylate (CAS: 41731-83-3) is typically synthesized through the reaction of 1,3-thiazole-5-carboxylic acid with bromoethylamine. This process involves the substitution of the amine group with a bromoethyl group, followed by esterification with ethanol. The reaction is catalyzed by a suitable base like sodium hydride and proceeds with good selectivity and a yield of up to 85%.