2,5-Bis(trifluoromethyl)phenol(CAS: 779-88-4)

2,5-Bis(trifluoromethyl)phenol (CAS: 779-88-4) is a colorless crystalline solid with a molecular weight of approximately 224.14 g/mol. It has low water solubility but good solubility in organic solvents such as acetone and methanol. Chemically, it is relatively stable but can react with strong bases to form trifluoromethyl phenol salts. It has high reactivity towards nucleophiles and can be used as a precursor in various organic syntheses.

2,5-Bis(trifluoromethyl)phenol can be synthesized via the reaction of 2,5-dichlorophenol with potassium trifluoroacetate in the presence of sodium hydroxide. The process typically yields a product with a high purity of over 95%. Other methods include the use of trifluoroacetic anhydride and phenol in the presence of a base. The reaction is highly selective and provides a good yield.

2,5-Bis(trifluoromethyl)phenol (CAS: 779-88-4) is used in various industries, including pharmaceuticals for the synthesis of drugs such as antivirals, in polymers for its flame retardant properties, in sensors for its ability to detect certain chemicals, and in semiconductors for its use in photoresists and etching processes.

When handling 2,5-Bis(trifluoromethyl)phenol (CAS: 779-88-4), use appropriate personal protective equipment such as gloves, safety goggles, and a lab coat. Store it in a well-ventilated area away from heat sources and reduce the risk of inhalation by working under a fume hood. In case of a spill, immediately clean with a suitable solvent and consult a Material Safety Data Sheet (MSDS) for detailed instructions.