N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide(CAS: 932986-18-0)

N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide is a crystalline solid with a molecular weight of approximately 367.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetonitrile. This compound is relatively stable but reacts with strong bases to form salts. It is not flammable and has a pKa of approximately 6.5.

N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide is typically synthesized through a multi-step process involving the coupling of 4-chloroaniline with thiazole, followed by butylation. This process often uses coupling agents such as EDC and NHS, and the reaction is carried out in the presence of a base like triethylamine. The overall yield is moderate, around 50-70%, and the reaction is conducted under mild conditions to ensure high selectivity.

N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide is primarily used in the pharmaceutical industry for the development of new drugs. It is also utilized in the polymer industry for its potential to improve the properties of certain polymers. Additionally, it has applications in the sensor and semiconductor industries due to its unique chemical and physical properties.

When handling N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly washed down. Always consult the SDS for specific safety guidelines and emergency procedures.