(3S)-3-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid(CAS: 755749-11-2)

(3S)-3-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid has a crystalline form and a molecular weight of approximately 300.09 g/mol. It is slightly soluble in water but soluble in organic solvents. The compound exhibits moderate reactivity, particularly towards nucleophiles. It has a pKa of 2.3 in water, indicating acidic behavior.

(3S)-3-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid is typically synthesized via amidation of 3-(2-(trifluoromethyl)phenyl)propionyl chloride with ammonia in the presence of a base like triethylamine. The reaction is carried out at room temperature and yields up to 90% product purity.

(3S)-3-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid is used in the pharmaceutical industry for the production of certain drug candidates. It may also have applications in the polymer industry for functionalizing polymers and in the sensor industry for developing chemical sensors.

When handling (3S)-3-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and protective clothing. Store the compound in a fume hood and in a cool, dry place away from direct sunlight. In case of spill, use a spill kit and ensure proper disposal following the Material Safety Data Sheet (MSDS) guidelines.