2-Methyl 1-(2-methyl-2-propanyl) (2S,4S)-4-cyano-1,2-pyrrolidinedicarboxylate(CAS: 487048-28-2)

2-Methyl 1-(2-methyl-2-propanyl) (2S,4S)-4-cyano-1,2-pyrrolidinedicarboxylate is a crystalline compound with a molecular weight of approximately 292.28 g/mol. It has a high solubility in organic solvents like DMSO and poor solubility in water. The compound is reactive, particularly with bases and reducing agents. It exhibits moderate reactivity in esterification and amidation reactions.

2-Methyl 1-(2-methyl-2-propanyl) (2S,4S)-4-cyano-1,2-pyrrolidinedicarboxylate can be synthesized via a multi-step process involving the cyanation of 2-methyl-2-propanol followed by a Wittig reaction. Commonly used catalysts include triphosgene and triphenylphosphine. The yield is typically around 75-85%, with high selectivity for the desired stereochemistry.

2-Methyl 1-(2-methyl-2-propanyl) (2S,4S)-4-cyano-1,2-pyrrolidinedicarboxylate finds application in pharmaceuticals for the synthesis of certain drug intermediates. It is also used in the polymer industry for the development of advanced polymers with specific properties. Additionally, it has potential applications in the production of sensors and semiconductors due to its unique chemical structure.

When handling 2-Methyl 1-(2-methyl-2-propanyl) (2S,4S)-4-cyano-1,2-pyrrolidinedicarboxylate, strict safety precautions must be followed. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be handled using suitable absorbent materials, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed instructions and emergency procedures.