4-Hydroxy-6-methyl-3-nitro-2(1H)-pyridinone(CAS: 4966-90-9)

4-Hydroxy-6-methyl-3-nitro-2(1H)-pyridinone is a crystalline compound with a molecular weight of approximately 212.12 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is reactive towards nucleophiles and can undergo nitro reduction. It has a melting point of about 220-222°C and a boiling point of around 250°C at reduced pressure.

4-Hydroxy-6-methyl-3-nitro-2(1H)-pyridinone can be synthesized via nitration of 4-hydroxy-6-methyl-2(1H)-pyridinone. Commonly, this is achieved in the presence of concentrated nitric acid and sulfuric acid as a catalyst. The reaction requires appropriate temperature control to achieve high yield and selectivity. The product is then purified using recrystallization from a suitable solvent.

4-Hydroxy-6-methyl-3-nitro-2(1H)-pyridinone is used in various industries, particularly in pharmaceuticals for its role as an intermediate in the synthesis of certain drugs. It is also utilized in the production of polymers, sensors, and semiconductors due to its unique chemical properties. Its reactivity and functionality make it a valuable compound in these applications.

Proper safety measures are essential when handling 4-Hydroxy-6-methyl-3-nitro-2(1H)-pyridinone. Always wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work in a well-ventilated area or a fume hood to minimize inhalation risk. Store the compound in a cool, dry place, away from heat and ignition sources. In case of spill, carefully contain it and follow the safety data sheet (SDS) for disposal instructions.