3-Chloro-5-hydroxybenzonitrile(CAS: 473923-97-6)

3-Chloro-5-hydroxybenzonitrile is a crystalline solid with a molecular weight of approximately 194.58 g/mol. It has a high solubility in polar solvents like water and methanol. Chemically, it is highly reactive towards nucleophiles and can undergo substitution and addition reactions. It is also prone to hydrolysis under basic conditions.

3-Chloro-5-hydroxybenzonitrile is synthesized through a multi-step process involving chlorination of a hydroxybenzonitrile derivative. Commonly, a phenol derivative is nitrated first, followed by chlorination, and finally hydrolysis. This process often uses sulfuric acid and chlorine gas as reagents, with good selectivity and yield.

3-Chloro-5-hydroxybenzonitrile is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the modification of polymers and in the semiconductor industry for the production of organic semiconductors and sensors.

Proper personal protective equipment (PPE) is essential when handling 3-Chloro-5-hydroxybenzonitrile. Wear gloves, safety glasses, and a lab coat. Store it in a cool, well-ventilated area away from direct sunlight. Use a fume hood during handling to prevent inhalation. In case of spill, neutralize with an appropriate reagent and follow the safety data sheet (SDS) for disposal.