4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid(CAS: 106261-48-7)

4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid (CAS: 106261-48-7) is a white crystalline solid with a molecular weight of approximately 287.36 g/mol. It has a pKa of 4.75 and is soluble in alcohol and slightly soluble in water. The compound is moderately reactive towards basic conditions and can undergo esterification and amide formation. It has a melting point of about 185-187°C.

4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid (CAS: 106261-48-7) can be synthesized via the condensation of 4-(methylpiperazin-1-yl)benzaldehyde with benzoic acid in the presence of a catalyst like p-toluenesulfonic acid (p-TSA). The reaction yields a high yield of the desired compound with good selectivity. The process typically involves refluxing the mixture under inert conditions for a few hours.

4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid (CAS: 106261-48-7) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of functional polymers. Additionally, it finds applications in sensors and as a building block in semiconductor materials.

When handling 4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid (CAS: 106261-48-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Store the compound in a well-ventilated area and consider using a fume hood to minimize inhalation exposure. Follow standard laboratory safety procedures and keep a copy of the Safety Data Sheet (SDS) readily available for reference. In the event of a spill, contain it with absorbent material and dispose of it according to local regulations.