Mono-(6-p-toluenesulfonyl)-β-cyclodextrin(CAS: 67217-55-4)

Mono-(6-p-toluenesulfonyl)-β-cyclodextrin (CAS: 67217-55-4) is a white crystalline powder with a molecular weight of approximately 1485 g/mol. It has excellent solubility in organic solvents such as methanol and ethanol but is insoluble in water. The compound exhibits moderate reactivity due to the presence of the toluenesulfonyl group, which can undergo hydrolysis under basic conditions. It is stable under normal storage conditions but should be protected from moisture and heat.

Mono-(6-p-toluenesulfonyl)-β-cyclodextrin (CAS: 67217-55-4) is synthesized by the reaction of 6-p-toluenesulfonyl chloride with β-cyclodextrin in the presence of a suitable base such as triethylamine. The reaction requires a neutral to slightly basic environment and typically yields a product with high purity. The process involves careful temperature and time control to ensure the desired product is formed with high selectivity and yield.

Mono-(6-p-toluenesulfonyl)-β-cyclodextrin (CAS: 67217-55-4) is used in various industries including pharmaceuticals, where it can be used as a stabilizer or carrier for drugs. It is also utilized in the production of sensors and semiconductors due to its unique physicochemical properties. Additionally, it can be found in polymer synthesis as a modifier and in the formulation of cosmetics and personal care products.

When handling Mono-(6-p-toluenesulfonyl)-β-cyclodextrin (CAS: 67217-55-4), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from heat sources and incompatible substances. Spills should be cleaned up immediately using appropriate absorbent materials. Emergency showers and eye wash stations should be readily available. Always consult the safety data sheet (SDS) for detailed handling and safety information.