3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]propanoic acid(CAS: 20170-32-5)

3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]propanoic acid is a crystalline solid with a molecular weight of approximately 346.45 g/mol. It has a pKa of ~5.3, indicating it is slightly acidic. The compound is poorly soluble in water but soluble in common organic solvents like dichloromethane and ethanol. It exhibits good reactivity towards nucleophiles and can undergo esterification and condensation reactions.

3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]propanoic acid can be synthesized through a multi-step process involving the condensation of 2,2-dimethylpropionaldehyde with 4-hydroxy-3,5-dimethylphenol, followed by an esterification reaction. This compound is often obtained using mild conditions, with catalysts such as sulfuric acid or p-toluenesulfonic acid, to achieve a yield of about 75-80%.

3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]propanoic acid is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry as a stabilizer and in the production of functional polymers. Additionally, it is used in the development of sensor materials and in the semiconductor industry for specific applications.

Proper handling of 3-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]propanoic acid requires the use of personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be stored in a closed container in a cool, dry place, away from heat sources and incompatible materials. Spills should be handled with caution, and spill cleanup procedures should follow safety data sheet (SDS) guidelines to avoid exposure and environmental pollution.