4,4-Dimethoxybutanenitrile(CAS: 14618-78-1)

4,4-Dimethoxybutanenitrile (CAS: 14618-78-1) is a colorless liquid with a molecular weight of approximately 150.16 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly with nucleophiles, and can undergo nitrile hydrolysis to form carboxylic acids under basic conditions.

4,4-Dimethoxybutanenitrile is typically synthesized via the reaction of ethyl cyanoacetate with methanol in the presence of a base like potassium methoxide. The reaction yields the desired product with good selectivity and high yield. Additional methods involve the hydrolysis of 4,4-dimethoxy-1,3-butandione nitrile under basic conditions.

4,4-Dimethoxybutanenitrile (CAS: 14618-78-1) finds applications in the pharmaceutical industry as an intermediate in the synthesis of various compounds. It is also used in the polymer industry for the modification of polymer properties. Additionally, it is used in the production of sensors and as a reagent in semiconductor manufacturing.

When handling 4,4-Dimethoxybutanenitrile (CAS: 14618-78-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Use a fume hood to minimize inhalation risks. In case of a spill, immediately clean it up using an appropriate absorbent material and follow local safety guidelines. Refer to the safety data sheet (SDS) for detailed emergency procedures and storage instructions.