3-Amino-1H-pyrazol-5(4H)-one(CAS: 6126-22-3)

3-Amino-1H-pyrazol-5(4H)-one is a crystalline solid with a molecular weight of approximately 132.13 g/mol. It is slightly soluble in water and sparingly soluble in ethanol. It reacts with acids and bases, and is known to form stable complexes with metal ions. The compound has a melting point of 228-230 °C and is stable under normal conditions.

3-Amino-1H-pyrazol-5(4H)-one is commonly synthesized via the condensation of 3-formylpyrazole with ammonia in the presence of a catalyst such as potassium hydroxide. The reaction is carried out in an aqueous medium and yields a product with high purity. The method is selective and provides a yield of around 70-80%.

3-Amino-1H-pyrazol-5(4H)-one is used in various industries. It serves as a precursor in the synthesis of pharmaceuticals, where it is used to create intermediates for drug development. In the polymer industry, it is used as a monomer for the production of functionalized polymers. Additionally, it finds applications in the development of sensors due to its chemical reactivity and in the semiconductor industry for its electronic properties.

When handling 3-Amino-1H-pyrazol-5(4H)-one, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The substance should be handled in a well-ventilated area or a fume hood. In case of spillage, it is recommended to use appropriate spill cleanup materials and avoid inhaling the dust or fumes. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.