methyl 2-chloro-3-oxobutanoate(CAS: 4755-81-1)

Methyl 2-chloro-3-oxobutanoate (CAS: 4755-81-1) is a crystalline compound with a molecular weight of approximately 147.57 g/mol. It is poorly soluble in water but soluble in organic solvents. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

Methyl 2-chloro-3-oxobutanoate can be synthesized through the condensation of methyl acetoacetate with phosphorus oxychloride in the presence of a drying agent. The reaction typically yields a high purity product with good selectivity and a good yield of about 85%. The reaction is carried out under anhydrous conditions to avoid hydrolysis.

Methyl 2-chloro-3-oxobutanoate (CAS: 4755-81-1) is used in the pharmaceutical industry for the synthesis of certain drugs due to its reactivity and specific functional groups. It is also utilized in the polymer industry for the modification of polymer properties and in sensor technology for detection of specific analytes.

When handling methyl 2-chloro-3-oxobutanoate (CAS: 4755-81-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or within a fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. It is advisable to refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.