1-[4-(Trifluoromethyl)phenyl]-1-propanone(CAS: 711-33-1)

1-[4-(Trifluoromethyl)phenyl]-1-propanone (CAS: 711-33-1) is a colorless to light yellow liquid. It has a molecular weight of approximately 218.13 g/mol and a boiling point of about 157°C. The compound is moderately soluble in water but highly soluble in organic solvents such as ethanol and acetone. It is moderately reactive, undergoing hydrolysis and other substitution reactions under basic conditions. It is also prone to oxidation under certain conditions.

1-[4-(Trifluoromethyl)phenyl]-1-propanone (CAS: 711-33-1) can be synthesized via a Friedel-Crafts acylation reaction. This involves the reaction of 4-(trifluoromethyl)benzoyl chloride with acetone in the presence of aluminum chloride as a Lewis acid catalyst. The reaction typically provides high yields and good selectivity, making it a suitable method for industrial-scale production.

1-[4-(Trifluoromethyl)phenyl]-1-propanone (CAS: 711-33-1) is utilized in various industries including pharmaceuticals, where it serves as a precursor in the synthesis of certain drugs, and in the chemical industry for its use as a monomer in the production of polymers. It is also used in the development of sensors and as an intermediate in the semiconductor industry.

When handling 1-[4-(Trifluoromethyl)phenyl]-1-propanone (CAS: 711-33-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Ensure the use of a fume hood to minimize inhalation of vapors. Store the compound in a cool, well-ventilated area away from heat and ignition sources. In case of a spill, neutralize the acid by washing with water and dispose of the waste in accordance with local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.