7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide(CAS: 22503-72-6)

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide is a white crystalline solid with a molecular weight of approximately 246.03 g/mol. It has a solubility of 1.7 g/L in water at 25°C. The compound is known for its reactivity with nucleophiles and its stability under acidic conditions. It is commonly used in pharmaceuticals and other applications requiring its specific chemical properties.

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide is synthesized through a multi-step process involving chlorination followed by benzothiadiazine formation. The reaction typically involves a condensation step using Lewis acids as catalysts, followed by chlorination with thionyl chloride. The final product is isolated by recrystallization and has a yield of around 75-85%.

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the production of polymers and sensors due to its unique chemical properties. Its applications in semiconductors are limited but explored for specific functionalization purposes.

When handling 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a fume hood to minimize exposure to volatile compounds. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of a spill, neutralize the chemical with an appropriate reagent and dispose of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.