5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole(CAS: 119141-88-7)

5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole is a crystalline solid with a molecular weight of approximately 411.4 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and DMSO. Chemically, it is stable under normal conditions but may react with strong acids to form less stable derivatives. This compound is known for its reactivity towards nucleophiles and its ability to undergo sulfinyl substitution reactions.

5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole is synthesized via a multi-step process involving the formation of the 4-methoxy-3,5-dimethyl-2-pyridine methyl sulfinyl group and subsequent coupling with 5-methoxy-1H-benzimidazole. Commonly, this synthesis involves the use of tert-butyl chloroformate as a coupling agent and triethylamine as a base. The overall yield is typically around 70-80%, with good selectivity for the desired product.

5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole is mainly used in the pharmaceutical industry for its potential therapeutic properties. It is also explored in the sensor and semiconductor industries for its reactivity and electronic properties. This compound can be found in various formulations used in drug development and as a component in advanced sensor technologies.

When handling 5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.