Biotinyl-GHK tripeptide(CAS: 299157-54-3)

Biotinyl-GHK tripeptide is a crystalline compound with a molecular weight of approximately 498.44 g/mol. It is soluble in water but has poor solubility in organic solvents. The tripeptide exhibits moderate reactivity, particularly in the presence of reducing agents. It is stable under neutral conditions but can be sensitive to strong acids and bases.

Biotinyl-GHK tripeptide is typically synthesized through solid-phase peptide synthesis (SPPS) using standard Fmoc chemistry. The tripeptide is assembled on a solid support, with the biotin group introduced at the final step. Commonly, the biotinylation reaction involves the use of N-hydroxysuccinimide (NHS) ester biotin, which reacts selectively with the free amine group of the tripeptide to form an amide bond.

Biotinyl-GHK tripeptide is widely used in the pharmaceutical industry for skin care products due to its ability to stimulate collagen synthesis. It is also utilized in the cosmetic industry for anti-aging formulations. Additionally, it finds applications in bioconjugation for biosensors and as a component in peptide-based drug delivery systems.

When handling Biotinyl-GHK tripeptide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or under a fume hood. In case of a spill, immediately clean up using a suitable absorbent material and dispose of it according to laboratory waste protocols. Always refer to the safety data sheet (SDS) for detailed handling instructions.